Published: December 28, 2021 Abstract: Although cannabinoids have been used for centuries for diverse pathological conditions, recently, their clinical interest and application have emerged due to their diverse pharmacological properties. Indeed, it is well...
Research
cannabinoids
Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma
Published: February 5, 2021 Abstract: Glioblastoma is the most aggressive cancer among primary brain tumors. As with other cancers, the incidence of glioblastoma is increasing; despite modern therapies, the overall mean survival of patients' post-diagnosis averages...
Cannabinoids Block Cellular Entry of SARS-CoV‑2 and the Emerging Variants
Published: January 10, 2022 Abstract: As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity...
Bioengineering studies and pathway modeling of the heterologous biosynthesis of tetrahydrocannabinolic acid in yeast
Published: October 12, 2020 Abstract: Heterologous biosynthesis of tetrahydrocannabinolic acid (THCA) in yeast is a biotechnological process in Natural Product Biotechnology that was recently introduced. Based on heterologous genes from Cannabis sativa and...
Phytocannabinoids: a unified critical inventory
Published: January 2016 Abstract: Cannabis sativa L. is a prolific, but not exclusive, producer of a diverse group of isoprenylated resorcinyl polyketides collectively known as phytocannabinoids. The modular nature of the pathways that merge into the...
Metabolic Engineering Strategies of Industrial Hemp (Cannabis sativa L.): A Brief Review of the Advances and Challenges
Published: December 8, 2020 Abstract: Industrial hemp (Cannabis sativa L.) is a diploid (2n = 20), dioecious plant that is grown for fiber, seed, and oil. Recently, there has been a renewed interest in this crop because of its panoply of cannabinoids, terpenes, and...
Genomic and Chemical Diversity in Cannabis
Published: February 22, 2017 Abstract: Plants of the Cannabis genus are the only prolific producers of phytocannabinoids, compounds that strongly interact with the evolutionarily ancient endocannabinoid receptors shared by most bilaterian taxa. For millennia, the...
Processing and extraction methods of medicinal cannabis: a narrative review
Published: July 19, 2021 Abstract: Introduction: As the cannabis industry transitions from a black market to a legal market, product development, and methods of extraction have become a focal point. To date, more than thousands of chemical constituents have been...
The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
Published: February, 2020 Abstract: Mood disorders are the most prevalent mental conditions encountered in psychiatric practice. Numerous patients suffering from mood disorders present with treatment-resistant forms of depression, co-morbid anxiety, other psychiatric...
Cannabigerol Prevents Quorum Sensing and Biofilm Formation of Vibrio Harveyi
Published: May 7, 2021 Abstract: Cannabigerol (CBG) is a non-psychoactive cannabinoid naturally present in trace amounts in the Cannabis plant. So far, CBG has been shown to exert diverse activities in eukaryotes. However, much less is known about its effects on...