Published: December 28, 2021 Abstract: Although cannabinoids have been used for centuries for diverse pathological conditions, recently, their clinical interest and application have emerged due to their diverse pharmacological properties. Indeed, it is well...
Research
Cannabis sativa
An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia
Published: April 2019 Abstract: In this experimental randomized placebo-controlled 4-way crossover trial, we explored the analgesic effects of inhaled pharmaceutical-grade cannabis in 20 chronic pain patients with fibromyalgia. We tested 4 different cannabis varieties...
Architecture and Florogenesis in Female Cannabis sativa Plants
Published: April 2, 2019 Abstract: The inflorescence is the main product of medical cannabis. Hundreds of specialized metabolites with potential bioactivity are produced and accumulated in the glandular trichomes that are highly abundant mainly on female...
The Complex Interactions Between Flowering Behavior and Fiber Quality in Hemp
Published: May 6, 2019 Abstract: Hemp, Cannabis sativa L., is a sustainable multipurpose fiber crop with high nutrient and water use efficiency and with biomass of excellent quality for textile fibers and construction materials. The yield and quality of hemp biomass...
Bioengineering studies and pathway modeling of the heterologous biosynthesis of tetrahydrocannabinolic acid in yeast
Published: October 12, 2020 Abstract: Heterologous biosynthesis of tetrahydrocannabinolic acid (THCA) in yeast is a biotechnological process in Natural Product Biotechnology that was recently introduced. Based on heterologous genes from Cannabis sativa and...
Designing microorganisms for heterologous biosynthesis of cannabinoids
Published: June 2, 2019 Abstract: During the last decade, the use of medical Cannabis has expanded globally and legislation is getting more liberal in many countries, facilitating the research on cannabinoids. The unique interaction of cannabinoids with the human...
Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa
Published: January 18, 2016 Abstract: In polyketide biosynthesis, ring formation is one of the key diversification steps. Olivetolic acid cyclase (OAC) from Cannabis sativa, involved in cannabinoid biosynthesis, is the only known plant polyketide cyclase. In addition,...
PROGRESS IN EARLY SEX DETERMINATION OF CANNABIS PLANT BY DNA MARKERS
Published: 2016 Abstract: The cannabis plant is a tall annual crop of economic importance. It is mostly dioecious, but fiber hemp varieties have been bred to be monoecious. Separating male and female plants at early developmental stage is useful due to the influence...
Hermaphroditism in Marijuana (Cannabis sativa L.) Inflorescences – Impact on Floral Morphology, Seed Formation, Progeny Sex Ratios, and Genetic Variation
Published: June 25, 2020 Abstract: Cannabis sativa L. (hemp, marijuana) produces male and female inflorescences on different plants (dioecious) and therefore the plants are obligatory out-crossers. In commercial production, marijuana plants are all genetically female;...
Genomic and Chemical Diversity in Cannabis
Published: February 22, 2017 Abstract: Plants of the Cannabis genus are the only prolific producers of phytocannabinoids, compounds that strongly interact with the evolutionarily ancient endocannabinoid receptors shared by most bilaterian taxa. For millennia, the...