Published: November 25, 2019 Abstract: Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent...
Research
CBD
Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype
Published: December 28, 2021 Abstract: Although cannabinoids have been used for centuries for diverse pathological conditions, recently, their clinical interest and application have emerged due to their diverse pharmacological properties. Indeed, it is well...
Cannabigerol Is a Potential Therapeutic Agent in a Novel Combined Therapy for Glioblastoma
Published: February 5, 2021 Abstract: Glioblastoma is the most aggressive cancer among primary brain tumors. As with other cancers, the incidence of glioblastoma is increasing; despite modern therapies, the overall mean survival of patients' post-diagnosis averages...
A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
Published: November 2018 Abstract: Background: Cannabidiol is being pursued as a therapeutic treatment for multiple conditions, usually by oral delivery. Animal studies suggest oral bioavailability is low, but literature in humans is not sufficient. The aim of this...
Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
Published: March 10, 2021 Abstract: The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV2 infection. CBD and its metabolite, 7-OH-CBD, but not...
An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia
Published: April 2019 Abstract: In this experimental randomized placebo-controlled 4-way crossover trial, we explored the analgesic effects of inhaled pharmaceutical-grade cannabis in 20 chronic pain patients with fibromyalgia. We tested 4 different cannabis varieties...
Bioengineering studies and pathway modeling of the heterologous biosynthesis of tetrahydrocannabinolic acid in yeast
Published: October 12, 2020 Abstract: Heterologous biosynthesis of tetrahydrocannabinolic acid (THCA) in yeast is a biotechnological process in Natural Product Biotechnology that was recently introduced. Based on heterologous genes from Cannabis sativa and...
Cannabinoid Decarboxylation: A Comparative Kinetic Study
Published: October 20, 2020 Abstract: Cannabinoids like Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabigerol (CBG) are considered the main active components in Cannabis sativa L. and are obtained through the decarboxylation of their acid analogues (THCA,...
Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers
Published: December 14, 2016 Abstract: Background: Cannabidiol (CBD) is a naturally occurring constituent of the marijuana plant. In the past few years, there has been great interest in the therapeutic effects of isolated CBD and it is currently being explored for...
The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders
Published: February, 2020 Abstract: Mood disorders are the most prevalent mental conditions encountered in psychiatric practice. Numerous patients suffering from mood disorders present with treatment-resistant forms of depression, co-morbid anxiety, other psychiatric...